Briar Creek - A commercial and residential area of development in northwest Raleigh.
Capital - Capital Boulevard in Raleigh.
CAT - The Capital Area Transit bus service serving Raleigh.
CH - Chapel Hill.
Crabtree - Generally refers to the area around Crabtree Mall in Raleigh.
DPAC - Durham Performing Arts Center.
DTR - Downtown Raleigh.
Duke - In a home listing, this probably refers to either Duke University or Duke University Hospital.
Five Points - A suburb of downtown Raleigh.
FV (or F-V) - The town of Fuquay-Varina.
Glenwood - Glenwood Avenue in Raleigh.
HS - Depending on the context, this could mean "high school" or it could refer to the town of Holly Springs.
H-T (or HT) - May refer to Harris-Teeter, a popular area grocery store chain.
ITB - Inside the Beltline. Refers to the part of Raleigh located within the circular boundary of I-440 (aka, the Beltline).
JoCo - Johnston County.
Mordecai - A historic suburb of downtown Raleigh.
NCSU - North Carolina State University.
Oakwood - A historic suburb of downtown Raleigh.
OC - Orange County.
PNC - The PNC Arena, Raleigh's largest indoor sports and entertainment venue.
RBC - RBC Center is the former name of what is now the PNC Arena.
RDU - Raleigh-Durham International Airport.
R-LINE - A free bus service in downtown Raleigh.
RTP - Research Triangle Park.
TWC - Time-Warner Cable.
UNC - Refers to UNC Hospitals in Chapel Hill or the University of North Carolina at Chapel Hill.
Wade - Wade Avenue in Raleigh.
WCPSS - Wake County Public School System.
WF - The town of Wake Forest (depending on the context).
If you know of any others, please share in the comments!